Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
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چکیده
منابع مشابه
postnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Neurotoxicity of general anesthetics: cause for concern?
GENERAL anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles, and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and elimination. But recent laboratory data call fo...
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A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. Though general anesthetics have now been used clinically for well over a century, both their mechanisms of action as well as the nature o...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 2019
ISSN: 0892-0362
DOI: 10.1016/j.ntt.2018.11.004